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What is cocaine?

Cocaine, or coke as it is commonly known, is a stimulant and has a similar effect to amphetamines like speed and ice, but produces a more intense effect and shorter ‘high’ depending upon dosage. Cocaine is a white crystalline powder with a bitter numbing taste.
Cocaine hydrochloride can be further processed to produce cocaine base, which comes in two forms known as freebase and crack. Freebase is also a white powder, while crack generally comes in the form of crystals ranging in colour from white or creamy to transparent with a pink or yellow tinge.
Cocaine is known by a variety of other names, including: coke, Charlie, blow, C, pepsi, nose candy. Crack cocaine is also known as a variety of other names, including: rock, base and sugar block.
Pure cocaine was originally extracted from the leaf of the Erythroxylon coca bush, which grew primarily in Peru and Bolivia. After the 1990s, and following crop reduction efforts in those countries, Colombia became the nation with the largest cultivated coca crop. Today, cocaine is a Schedule II drug, which means that it has high potential for abuse but can be administered by a doctor for legitimate medical uses, such as local anesthesia for some eye, ear, and throat surgeries.
Cocaine is generally sold on the street as a fine, white, crystalline powder and is also known as “coke,” “C,” “snow,” “flake,” or “blow.” Street dealers generally dilute it with inert substances such as cornstarch, talcum powder, or sugar, or with active drugs such as procaine (a chemically related local anesthetic) or amphetamine (another stimulant). Some users combine cocaine with heroin-in what is termed a “speedball.”
There are two chemical forms of cocaine that are abused: the water-soluble hydrochloride salt and the water-insoluble cocaine base (or freebase). When abused, the hydrochloride salt, or powdered form of cocaine, can be injected or snorted. The base form of cocaine has been processed with ammonia or sodium bicarbonate (baking soda) and water, and then heated to remove the hydrochloride to produce a smokable substance. The term “crack,” which is the street name given to freebase cocaine, refers to the crackling sound heard when the mixture is smoked.

How does cocaine produce its effects?
Research has led to a clear understanding of how cocaine produces its pleasurable effects and why it is so addictive. Scientists have discovered regions within the brain that are stimulated by all types of reinforcing stimuli such as food, sex, and many drugs of abuse. One neural system that appears to be most affected by cocaine originates in a region of the midbrain called the ventral tegmental area (VTA).
Nerve fibers originating in the VTA extend to a region known as the nucleus accumbens, one of the brain's key areas involved in reward.
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